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Laura P. James, M.D.

Picture of Picture ofLaura P. James
  • Professor, College of Medicine, Department of Pediatrics


  • Pharmacology and Toxicology


  • Pharmacology/Toxicology

Contact Information

  • Email:
    Phone: 501-364-1418
    Fax: 501-364-3551
    Address: Arkansas Children's Hospital
    1 Children's Way
    Little Rock, AR 72202


  • B.S., Furman University, 1985
  • M.D., Univ of South Carolina, 1989


  • Residency, Pediatrics, University of Arkansas for Medical Sciences, 1989-1992
  • Fellowship, Pharmacology/Toxicology, University of Arkansas for Medical Sciences, 1994-1996
  • Fellowship, Emergency Medicine, University of Alabama at Birmingham, 1992-1994

Licensure and Board Certification

  • American Board of Medical Specialties, Pediatrics, Pediatric Emergency Medicine
  • American Board of Medical Specialties, Pediatrics, Pediatrics

Clinical & Research Interests

  • Basic Science, Clinical Research, Translational Research, Acetaminophen toxicity, mechanisms of liver repair in acetaminophen toxicity, clinical trials of drugs in children in order to gain dose and safety information

Recent Honors

  • Inaugural Fellow, Arkansas Research Alliance (ARA), 2014
  • The Best Doctors in America, Woodward & White, Inc, 2015

Recent Publications

  • Journal Article, Dobson NR., Liu X., Rhein LM., Darnall RA., Corwin MJ., McEntire BL., Ward RM., James LP., Sherwin CM., Heeren TC., Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. Br J Clin Pharmacol 2016 Sep; 82(3):754-61.
  • Journal Article, Cho NE., Bang BR., Gurung P., Li M., Clemens DL., Underhill TM., James LP., Chase JR., Saito T. Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology 2016 Jun; 63(6):1783-95.
  • Journal Article, Beger RD., Bhattacharyya S., Yang X., Gill PS., Schnackenberg LK., Sun J., James LP. Translational biomarkers of acetaminophen-induced acute liver injury. Arch Toxicol 2015 89:1497-1522.
  • Journal Article, Yang X., Salminen WF., Shi Q., Greenhaw J., Gill PS., Bhattacharyya S., Beger R., Mendrick DL., Mattes WB., James LP. Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. TAAP 2015 284(2):180-7.
  • Journal Article, James LP., Yan K., Pence L., Bhattacharyya S., Gill P., Letzig L., Kearns GL., Beger RD. Comparison of bile acids and acetaminophen protein adducts in children and adolescents with acetaminophen toxicity. Plos One 2015 Jul; 10(7):e0131010. doi: 10.1371/journal.pone.0131010. eCollection 2015..
  • Journal Article, Alonso EM., James LP., Zhang S., Squires RH., Pediatric Acute Liver Failure Study Group. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute. J Pediatr Gastrenterol Nutr 2015 Jul; 61(1):102-7.
  • Journal Article, Hartman JH., Letzig LG., Roberts DW., James LP., Fifer EK., Miller GP. Metabolism of Acetaminophen and Styrene Mixtures. Biochem Pharmacol 2015 97:341-9.
  • Journal Article, Miyakawa K., Albee R., Letzig LG., Lehner AF., Scott MA., Buchweitz JP., James LP., Ganey PE., Roth RA. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes. J Pharmacol Exp Ther 2015 Aug; 354(2):230-7.
  • Journal Article, Redwine KM., James LP., O'Riordan M., Sullivan JE., Blumer JL., Network of Pediatric Pharmacology Research Units. Accuracy of the Spacelabs 90217 ambulatory blood pressure monitor in a pediatric population. Blood Press Monit 2015 Oct; 20(5):295-8.
  • Journal Article, Banerjee S., Melnyk SB., Krager KJ., Aykin-Burns N., Letzig LG., James LP., Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med 2015 Oct; 9(89):750-57.

Recent Grant Awards

  • A Phase 2/3, Randomized, Open-Label, Multi-center study to Determine the Safety and Efficacy of Solithromycin in Adolescents and Children with Suspected or Confirmed Community-Acquired Bacterial Pneumonia, NIH, 6690/5926-01, 2016-04-27 00:00:00-2018-05-23 00:00:00
  • AcetaSTAT Rapid Assay for Acetaminophen Liver Injury (ATD Phase 2), NIH, 2R42DK079387-06A1, 2016-04-01 00:00:00-2019-03-31 00:00:00
  • Amicus Therapeutics, Inc., Amicus Therapeutics, Inc. , AT1001-041, 2014-05-15 00:00:00-2019-04-30 00:00:00
  • An Open-Label Study of the Pharmacokinetics of a Single Dose of Telavancin in Pediatric Subjects Aged 1 to 17 Years, Theravance, 0101 Telavancin, 2014-06-01 00:00:00-2017-10-31 00:00:00
  • Debio 1450 and Debio 1452 testing, Debiopharm, Debio 1450 1452, 2016-08-15 00:00:00-2018-08-15 00:00:00
  • Measurement of Acetaminophen Protein Adducts in Blood Samples using HPLC, GlaxoSmithKline, Acetaminophen Adduct Assay, 2010-07-30 00:00:00-2017-06-30 00:00:00
  • Pharmacokinetics of Clindamycin and Trimethoprim-Sulfamethoxazole in Infants and Children, NICHD, PBPK_R01; R01HD076676, 2015-10-01 00:00:00-2017-10-31 00:00:00
  • Serum Acetaminophen Protein Adduct Testing for Subjects in sirukumab Phase 3 protocols, Jannsen, HPLC-EC, 2014-01-01 00:00:00-2018-12-31 00:00:00
  • Single-Dose Study testing a Rivaroxaban Dry Powder Formulation for Oral Suspension in Children from 6 months to 12 years with Previous Thrombosis, Bayer, 17992, 2015-09-01 00:00:00-2017-08-31 00:00:00

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