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Faculty

Dean W. Roberts, Ph.D.

Picture of Picture ofDean W. Roberts
  • College of Medicine, Department of Pharmacology and Toxicology
  • Associate Professor, College of Medicine, Department of Pediatrics

Sections

  • Pharmacology and Toxicology

Specialties

  • Basic Scientist

Contact Information

  • Email: RobertsDeanW@uams.edu
    Phone: 501-364-1418
    Fax: 501-364-3551
    Address: Arkansas Children's Hospital
    1 Children's Way
    Little Rock, AR 72202

Education

  • B.A., Emory University, 1967
  • M.S., Hahnemann Medical College, 1975
  • Ph.D., Hahnemann Medical College, 1977

Training

  • Predoctoral Trainee, Microbiology and Immunology, Hahnemann Medical College, 1973-1977
  • Staff Fellow, Research Microbiologist, Immunotoxicology Program, National Center for Toxicological Research, 1977-1979

Clinical & Research Interests

  • Clinical Research, Pharmacology, toxicology, immunology

Recent Publications

  • Journal Article, Hartman JH., Letzig LG., Roberts DW., James LP., Fifer FK. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochemical Pharmacology 2015
  • Journal Article, Hartman JH., Letzig LG., Roberts DW., James LP., Fifer EK., Miller GP. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem Pharmacol 2015 Oct; 97(3):341-9.
  • Journal Article, James LP., Chiew A., Abdel-Rahman SM., Letzig L., Graudins A., Day P., Roberts DW. Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol 2013 Apr; 69(4):851-7.
  • Journal Article, Yang X., Greenhaw J., Shi Q., Roberts DW., Hinson JA., Muskhelishvili L., Davis K., Salminen WF. Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther 2013 Jan; 344(1):286-94.
  • Journal Article, James LP., Roberts DW. Isoniazid Hepatotoxicity: Progress in Understanding the Immunologic Component. Hepatology 2013 59(3):746-8.
  • Journal Article, Yang X., Greenhaw J., Ali A., Shi Q., Roberts DW., Hinson JA., Muskhelishvili L., Beger R., Pence LM., Ando Y., Sun J., Davis K., Salminen WF. Changes in mouse liver protein glutathionylation after acetaminophen exposure. J Pharmacol Exp Ther 2012 Feb; 340(2):360-8.
  • Journal Article, Zhou X., Wei Y., Xie F., Laukaitis CM., Karn RC., Kluetzman K., Gu J., Zhang QY., Roberts DW., Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Mol Pharmacol 2011 April; 79(4):710-23.
  • Journal Article, Agarwal R., MacMillan-Crow LA., Rafferty TM., Saba H., Roberts DW., Fifer EK., James LP., Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J PHarmacol Exp Ther 2011 April; 337(1):110-6.
  • Journal Article, James L., Sulivan JE., Roberts DW. The Proper Use of Acetaminophen. Paediatr Child Health 2011 Nov; 16(9):544-547.
  • Journal Article, Mercer KE., Apostolov EO., da Costa GG., Yu X., Lang P., Roberts DW., Davis W., Basnakian AG., Kadlubar FF., Kadlubar SA. Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increased 4-hydroxytamoxifen-induced apoptosis.. Int J Mol Epidemiol Genet 2010 January; 1(2):92-103.

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