UAMS Pediatrics

• Professor, College of Medicine, Department of Pediatrics
• Professor, College of Medicine, Department of Neurobiology & Developmental Science
• Professor, College of Medicine, Department of Internal Medicine

Sections

• Critical Care Medicine

Specialties

Contact Information

• Email:	ealchaer@uams.edu
  Phone:	501-526-7828
  Fax:	501-526-7862
  Address:	University of Arkansas for Medical Sciences
  	4301 W. Markham St., Slot 842
  	Little Rock, AR 72205

Education

• B.S., American University of Beirut, 1988
• M.S., American University of Beirut, 1991
• Ph.D., University of Texas Medical Branch, 1996
• J.D., South Texas College of Law, 2002

Training

• Post-Doctoral Fellow, Pediatrics, University of Texas Medical Branch, 1997-1998

Clinical & Research Interests

• Basic Science, Translational Research, Pain, neonatal pain, visceral pain, long-term effects of neonatal injury, sex differences in pain, sex hormones and pain, sex hormones and development, neuroscience, spinal cord, neuronal sensitization, glial activaion

Recent Honors

• Invited plenary speaker, Title of Talk: "Irritable Bowel Syndrome: A Tale of Sex, Drugs and Pain.", The Institute of Chinese Medicine Forum on IBS, Hong Kong, 2009

Recent Publications

• Journal Article, Chaloner A., Aao A., Al-Chaer ED., Greenwood-van Meerveld B. Repetitive colorectal distention in neonatal rats induces colonic mucosal and muscular dysfunction in adulthood. Int J Dev Neurosci. 2010 Feb; 28(1):99-103.
• Journal Article, Hayar A., Gu C., Al-Chaer ED. An improved method for patch clamp recording and calcium imaging of neurons in the intact dorsal root ganglion in rats.. J Neurosci Methods 2008 June; 173(1):74-82.
• Journal Article, Wang J., Gu C., Al-Chaer ED. Altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates. Behavioral and Brain Functions 2008 July; 4(1):28-.
• Journal Article, Saab CY, Wang J, Gu C, Garner KN, Al-Chaer ED. Microglia: A newly discovered role in visceral hypersensitivity?. Neuron Glia Biology 2007; 2(4):271-277.
• Journal Article, Grundy D, Al-Chaer ED, Aziz Q, Collins SM, Ke M, Tache Y, Wood JD. Fundamentals of neurogastroenterology: basic science. Gastroenterology 2006; 130(5):1391-1411.
• Journal Article, Lin C, Al-Chaer ED. Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. World J Gastroenterol 2005 Nov; 11(41):6495 - 6502.
• Journal Article, Arai YC, Ueda W, Al-Chaer ED. Pre-anesthetic presence of an injured dam influences pups' locomotor behavior during emergence from anesthesia in rats. Acta Anaesthesiol Scand 2005 Feb; 49(2):166 - 169.
• Journal Article, Saab CY, Park YC, Al-Chaer ED. Thalamic modulation of visceral nociceptive processing in adult rats with neonatal colon irritation. Brain Res 2004 May; 1008(2):186 - 192.
• Journal Article, Arai YC, Ueda W, Al-Chaer ED. Pre-anesthetic maternal separation increases pups' locomotor behavior during emergence from anesthesia in rats. Acta Anaesthesiol Scand 2004 Feb; 48(2):174 - 177.
• Journal Article, Kawasaki M, Al-Chaer ED. Intradermal capsaicin inhibits lumbar dorsal horn neuronal responses to colorectal distention. Neuroreport 2003 May; 14(7):985 - 989.

Recent Grant Awards

• Microglia in Chronic Visceral Pain, NIH/NIDDK, 5 R21 DK081628-02, 6/1/2009-5/31/2011
• Subaward - Spinal Microglial Mechanisms of Visceral Hypersensitivity, NIH/NIDDK, 1 R21 DK081845-01A2, 5/1/2010-4/30/2012
• Sex Hormones and Visceral Hypersensitivity, NIH/NIDDK, 5 R01 DK077733-03, 4/1/2008-3/31/2013