UAMS Pediatrics

• Associate Professor, College of Medicine, Department of Pediatrics
• xxxxxxxx, College of Medicine, Department of Pharmacology and Toxicology

Sections

• Pharmacology & Toxicology

Specialties

Contact Information

• Email:	RobertsDeanW@uams.edu
  Phone:	501-364-1418
  Fax:	501-364-3551
  Address:	Arkansas Children's Hospital
  	1 Children's Way
  	Little Rock, AR 72202

Education

• B.A., Emory University, 1967
• M.S., Hahnemann Medical College, 1975
• Ph.D., Hahnemann Medical College, 1977

Training

• Staff Fellow, Reasearch, National Center for Toxicological Research, 1977-1979
• Predoctoral Trainee, Microbiology and Immunology, Hahnemann Medical College, 1973-1977

Clinical & Research Interests

• Clinical Research, Pharmacology, toxicology, immunology

Recent Publications

• Journal Article, James LP., Letzig L., Simpson PM., Capparelli E., Roberts DW., Hinson JA., Davern TJ., Lee WM. Pharmacokinetics of Acetaminophen Protein Adduct in Adults with Acetaminophen Overdose and Acute Liver Failure.. Drug Metabolism Disposition 2009 August; 37(8):1-6.
• Journal Article, Gopee NV, Roberts DW, Webb P, Cozart CR, Siitonen PH, Warbritton AR, Yu WW, Colvin VL, Walker NJ, Howard PC. Migration of intradermally injected quantum dots to sentinel organs in mice. Toxicol Sci 2007 Jul; 98(1):249 - 257.
• Journal Article, Beland FA, Benson RW, Mellick PW, Kovatch RM, Roberts DW, Fang JL, Doerge DR. Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice. Food Chem Toxicol 2005 Jan; 43(1):1 - 19.
• Journal Article, Gorlewska-Roberts KM, Teitel CH, Lay JO, Roberts DW, Kadlubar FF. Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines. Chem Res Toxicol 2004 Dec; 17(12):1659 - 1666.
• Journal Article, Roberts DW, Doerge DR, Churchwell MI, Gamboa dC, Marques MM, Tolleson WH. Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover). J Agric Food Chem 2004 Oct; 52(21):6623 - 6632.
• Journal Article, Tolleson WH, Doerge DR, Churchwell MI, Marques MM, Roberts DW. Metabolism of biochanin A and formononetin by human liver microsomes in vitro. J Agric Food Chem 2002 Aug; 50(17):4783 - 4790.
• Journal Article, Roberts DW, Churchwell MI, Beland FA, Fang JL, Doerge DR. Quantitative analysis of etheno-2'-deoxycytidine DNA adducts using on-line immunoaffinity chromatography coupled with LC/ES-MS/MS detection. Anal Chem 2001 Jan; 73(2):303 - 309.
• Journal Article, Lavigne JA, Goodman JE, Fonong T, Odwin S, He P, Roberts DW, Yager JD. The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells. Cancer Res 2001 Oct; 61(20):7488 - 7494.
• Journal Article, Jenkins GR, Tolleson WH, Newkirk DK, Roberts DW, Rowland KL, Saheki T, Kobayashi K, Howard PC, Melchior WB. Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies. J Biochem Mol Toxicol 2000; 14(6):320 - 328.
• Journal Article, Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology 1999 Feb; 29(2):451 - 463.