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Richard E. Frye, M.D., Ph.D.

Picture of Picture ofRichard E. Frye
  • Associate Professor, College of Medicine, Department of Pediatrics


  • Neurology


  • Neurology

Contact Information

  • Email:
    Phone: 501-364-4662
    Address: Arkansas Children's Hospital Research Institute
    13 Children's Way
    Little Rock, AR 72202


  • B.A., C.W. Post of Long Island University, 1986
  • M.S., Drexel University, 1991
  • Ph.D., Georgetown University, 1998
  • M.D., Georgetown University, 1998


  • Resident , Pediatrics, Jackson Memorial Hospital, 1998-2000
  • Fellow , Behavioral Neurology and Learning Disabilities, Children's Hospital Boston, 2003-2005
  • Resident, Pediatric Neurology, Children's Hospital Boston, 2000-2003
  • Research Fellow, Psychology, Boston University, 2004-2005

Licensure and Board Certification

  • American Board of Medical Specialties, Pediatrics, Pediatrics
  • American Board of Medical Specialties, Psychiatry & Neurology, Neurology with Special Qualifications in Child Neurology

Recent Honors

  • Arkansas Biomedical Institute New Investigator Award, University of Arkansas for Medical Sciences, Little Rock, AR, 2013

Recent Publications

  • Journal Article, Deepmala, D., Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholzh, C., Frye, R. Clinical Trials of N-acetylcysteine in Psychiatry and Neurology: a systematic review. Neuroscience and biobehavioral reviews 2015 May; 6(55):294-321.
  • Journal Article, Frye, R. Sudden onset complex tic associated with streptococcal infection in a neonate: the first case of neonatal PANDAS. The North American Journal of Medicine and Science 2015 8(2):92-95.
  • Journal Article, Frye, R., MacFabe, DF. Gastrointestinal dysfunction in autism spectrum disorder: The role of the mitochondria and the enteric microbiome. Microbial Ecology in Health and Disease 2015 May; 7(26):27458.
  • Journal Article, Frye, R., Slattery, J., MacFabe, DF., Allen-Vercoe, E., Parker, W., Rodakis, J., Adams, JB., Krajmalnik-Brown, R., Bolte, E., Cerniglia, CE., Kahler, S., Jennings, J., James, SJ., Midtvedt, T. Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microbial Ecology in Health and Disease 2015 May; 7(26):26878.
  • Journal Article, Rose, S., Wynn, R., Frye, R., James, SJ. Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. Journal of Toxicology 2015
  • Journal Article, Tilford, JM., Payakachat, N., Kuhlthau, K., Pyne, JM., Kovacs, E., Bellando, J., Williams, DK., Brouwer, W., Frye, R. Treatment for sleep problems in children with autism and caregiver spillover effects. Journal of Autism and Developmental Disorders 2015 July;
  • Journal Article, Rossignol, DA., Frye, R. Evidence linking oxidative stress, mitochondrial dysfuntion and inflammation in the autism brain. Frontiers in Physiology 2014 5:150.
  • Journal Article, Rossignol, DA., Frye, R. The use of medications approved for Alzheimer's disease in autism spectrum disorder: a systematic review. Frontiers in Pediatrics 2014 2(87)
  • Journal Article, Rose, S., Frye, R., Slattery, J., Melnyk, S., Wynne, R., Tippett, M., James, SJ. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. Translational Psychiatry 2014 4:e377.
  • Journal Article, Frye, R., Rossignol, DA. Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder. Frontiers in Pediatrics 2014 2(66)

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