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Richard E. Frye, M.D., Ph.D.

Picture of Picture ofRichard E. Frye
  • Associate Professor, College of Medicine, Department of Pediatrics


  • Neurology


  • Neurology

Contact Information

  • Email:
    Phone: 501-364-4662
    Address: Arkansas Children's Hospital Research Institute
    13 Children's Way
    Little Rock, AR 72202


  • B.A., C.W. Post of Long Island University, 1986
  • M.S., Drexel University, 1991
  • Ph.D., Georgetown University, 1998
  • M.D., Georgetown University, 1998


  • Resident , Pediatrics, Jackson Memorial Hospital, 1998-2000
  • Resident, Pediatric Neurology, Children's Hospital Boston, 2000-2003
  • Fellow , Behavioral Neurology and Learning Disabilities, Children's Hospital Boston, 2003-2005
  • Research Fellow, Psychology, Boston University, 2004-2005

Licensure and Board Certification

  • American Board of Medical Specialties, Pediatrics, Pediatrics
  • American Board of Medical Specialties, Psychiatry & Neurology, Neurology with Special Qualifications in Child Neurology

Recent Publications

  • Journal Article, Frye, R.E., Sequeira, J.M., Quadros, E.V., James, S.J., Rossignol, D. Cerebral folate receptor autoantibodies in autism spectrum disorder.. Molescular Psyciatry 2013 Mar; 18:369-81.
  • Journal Article, Frye, R.E., Liederman, J., McGraw Fisher, J., Wu, M.H. Laterality of temporoparietal causal connectivity during the pre-stimulus period correlates with phonological decoding task performance in dyslexic and typical readers.. Cerebral Cortex 2013 Aug; 22:1923-34.
  • Journal Article, Leon-Carrion, J., Leon-Dominguez, U., Pollonini, L., Wu, M.H., Frye, R.E., Dominguez-Morales, M.R., Zouridakis, G. Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). Brain Res. 2013 Oct; 1476:22-30.
  • Journal Article, Liederman, J., Fisher, JM., Coty, A., Matthews, G., Frye, R.E., Lincoln, A., Alexander, R. Sex Differences in the Use of Delayed Semantic Context When Listening to Disrupted Speech. Arch Sex Behav 2013 Feb; 42:197-201.
  • Journal Article, Frye, R.E., DeLaTorre, R., Taylor, H., Slattery, J., ., Melnyk, S., James, S.J. Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease.. Translational Psychiatry 2013 3:e273.
  • Journal Article, Ellmore, T.M., Li, H., Xue, Z., Frye, R.E., Wong, S.T. Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder. Journal of the International Neuropsychological Society 2013 19:723-8.
  • Journal Article, Frye, R.E., ., Rossignol, D.A. Mitochondrial Physiology in Autism Spectrum Disorder. OA Autism 2013 1:5.
  • Journal Article, Frye, R.E., DeLaTorre, R., Taylor, H., Slattery, J., Melnyk, S., James, S.J. Metabolic Effects of Sapropterin Treatment in Autism Spectrum Disorder. Translational Psychiatry 2013 5:e237;
  • Journal Article, Frye, R.E., Melnyk, S., MacFabe, D. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry 2013 3:e220.
  • Journal Article, Frye, R.E. . A Lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality. Computers in Biology and Medicine 2013 43:962-965.

Recent Grant Awards

  • A Randomized, Double-Blind, Phase 2A Crossover Study to Assess the Safety and Efficacy of Trichuris Suis Ova for the Treatment of Autism Spectrum Disorder, Coronado, CNDO 201-101, 2014-06-01 00:00:00-2015-05-31 00:00:00
  • An Open-Label Extension Study of the Safety and Tolerability of Memantine in Pediatric Patients with Autism, Asperger's Disorder, or PDD-NOS - MEM-MD-69, Forest Labs, MEM-MD-69, 2012-05-01 00:00:00-2014-07-31 00:00:00
  • AT3, UCSF, 2013-09-01 00:00:00-2014-08-31 00:00:00
  • Frye General Research Account, 2013-01-01 00:00:00-2020-12-31 00:00:00
  • Health GFCF Modified Atkins Diet for Treating Seizures in Autism, Autism Research Institute, 2014-01-01 00:00:00-2014-12-31 00:00:00
  • Mitochondrial Dysfunction in Autism, Jane Botsford Johnson Foundation, 2013-01-01 00:00:00-2014-12-31 00:00:00

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