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Richard E. Frye, M.D., Ph.D.

Picture of Picture ofRichard E. Frye
  • Associate Professor, College of Medicine, Department of Pediatrics


  • Neurology


  • Neurology

Contact Information

  • Email:
    Phone: 501-364-4662
    Address: Arkansas Children's Hospital Research Institute
    13 Children's Way
    Little Rock, AR 72202


  • B.A., C.W. Post of Long Island University, 1986
  • M.S., Drexel University, 1991
  • Ph.D., Georgetown University, 1998
  • M.D., Georgetown University, 1998


  • Resident , Pediatrics, Jackson Memorial Hospital, 1998-2000
  • Fellow , Behavioral Neurology and Learning Disabilities, Children's Hospital Boston, 2003-2005
  • Resident, Pediatric Neurology, Children's Hospital Boston, 2000-2003
  • Research Fellow, Psychology, Boston University, 2004-2005

Licensure and Board Certification

  • American Board of Medical Specialties, Pediatrics, Pediatrics
  • American Board of Medical Specialties, Psychiatry & Neurology, Neurology with Special Qualifications in Child Neurology

Recent Honors

  • Arkansas Biomedical Institute New Investigator Award, University of Arkansas for Medical Sciences, Little Rock, AR, 2013

Recent Publications

  • Journal Article, Frye, RE., Rossignol DA. Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum disorder to Achieve Optimal Outcomes.. Clin Med Insights Pediatr 2016 Jun; 15(10):43-56.
  • Journal Article, Frye, RE., Casanova MF., Fatemi SH., Folsom TD., Reutiman TJ., Brown GL., Edelson SM., Slattery JC., Adams JB. Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder. Front Neurosci 2016 May; 10(10):192.
  • Journal Article, Frye, RE., Delhey L., Slattery J., Tippett M., Wynne R., Rose S., Kahler SG., Bennuri SC., Melnyk S., Sequeira JM., Quadros E. Front Neurosci. Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups 2016 Mar; 9
  • Journal Article, Frye, RE., Cox D., Slattery J., Tippett M., Kahler S., Granpeesheh D., Damle S., Legido A., Goldenthal MJ. Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome. Sci Rep 2016 Jan; 29(6):19544.
  • Journal Article, Hasan KM., Mwangi B., Cao B., Keser Z., Tustison NJ., Kochunov P., Frye, RE., Savatic M., Soares J. Entorhinal Cortex Thickness across the Human Lifespan. J Neuroimaging 2016 May; 26(3):278-82.
  • Journal Article, Frye, R.E., Tippett, M., Delhey, L., Slattery, J. Heterozygous deletion of MACROD2 is Associated with Autism Spectrum Disorder. The North American Jnl of Medicine and Science 2016 9; 1:35-37.
  • Journal Article, Frye, R.E., Delhey, L., Slattery, J., Tippett, M., Wynne, R., Rose, S., Kahler, S.G., Bennuri, S.C., Melnyk, S., Sequeira, J.M., Quadros, E. Blocking and binding folate receptor alpha autoantibodies identify novel autism spectrum disorder subgroups. Frontiers in Neuroscience 2016 (10:80)
  • Journal Article, Tilford JM., Payakachat N., Kuhlthau KA., Pyne JM., Kovacs E., Bellando J., Williams DK., Brouwer WB., Frye, RE. Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects. J Autism Dev Disord 2015 Nov; 45(11):3613-23.
  • Journal Article, Frye, RE. Introduction. Microb Ecol Health Dis 2015 May; 7:26:28168.
  • Journal Article, Samanta D., Ramakrishnaiah R., Willis E., Frye, RE. Myoclonic epilepsy evolved into West syndrome: a patient with a novel de novo KCNQ2 mutation. Acta Neurol Belg 2015 Sep; 115(3):475-8.

Recent Grant Awards

  • An Open-Label Extension Study of CM-AT for the Treatment of Children with Autism, Curemark, CMAT104, 2016-03-01 00:00:00-2017-02-28 00:00:00
  • Assessment of Gastrointestinal Symptoms, RTI Health Solutions, 0304359, 2016-07-21 00:00:00-2017-06-30 00:00:00
  • Children's Autism Metabolome Project (CAMP): Development and Clinical Evaluation of the Stemina Metabolic Biomarker-Based Test to Diagnose Autism Spectrum Disorder in Early Childhood , Stemina Biomarker Discovery, Inc., CAMP-01, 2015-05-28 00:00:00-2017-06-28 00:00:00
  • Effect of AIMs and HSP90 inhibitors on in Vitro Mitochondrial respiration in control and autism lymphoblastoid cell lines, Reata , 2016-05-13 00:00:00-2017-05-12 00:00:00
  • Frye General Research Account, 2013-01-01 00:00:00-2020-12-31 00:00:00
  • Phytocannabinoids protective effect on oxidative stress induced mitochondrial dysfunction in control and autistic cell lines., GW Pharmaceuticals, GWR-01412-DIS-ARA-00404, 2016-07-01 00:00:00-2017-06-30 00:00:00
  • Unique Mitochondrial Dysfunction in Autism Spectrum Disorder, ACH Fdt., 2016-02-01 00:00:00-2017-01-31 00:00:00

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